My primary goal is the development of highly sensitive early detection assays by integrating magnetic and optical nanoparticles. We have combined magnetic iron oxide nanoparticles and fluorescent semiconductor quantum dots (QD) in porous microbeads for potentially automated multiplexed assays. In addition, we are trying to combine magnetic nanoparticles with QDs for the selective capture and molecular analysis of rare tumor cells isolated from blood. As part of this project, we are also studying interactions between nanoparticles and live immune cells in whole blood as a function of surface properties and plasma content

Publications and Presentation

Publications:
Sathe T.R., Saheb A., Nie S.M., Integrating Magnetic and Optical Nanotechnology for Selective Capture and Multiplexed Analysis of Rare Tumor Cells, Proceedings of 6th IEEE Conference on Sensors, 2007

Sathe T.R., Nie S.M. Development of dual-function microbeads embedded with quantum dots and iron oxide nanocrystals for biomedical applications, Proceedings of SPIE, 2007

Sathe, T. R.; Agrawal, A.; Nie, S. M. "Mesoporous Silica Beads Embedded with Semiconductor Quantum Dots and Iron Oxide Nanocrystals: Dual-Function Microcarriers for Optical Encoding and Magnetic Separation", Anal.Chem. 2006, 78, 5627-5632 (Featured on Journal Cover)

Agrawal A, Sathe T.R., Nie S.M. Nanotechnology tools for microbial pathogens, Wiley Interdisciplinary Reviews: Nanomedicine, Edited by James Baker, 2007 (in preparation)

Agrawal A, Sathe T.R., Nie S.M. Single-Bead Immunoassays Using Magnetic Microparticles and Spectral-Shifting Quantum Dots, J. Agric. Food Chem., 55 (10), 3778 -3782, 2007. 2007

Agrawal A, Sathe T.R., and Nie S.M., "Nanoparticle Probes for Ultrasensitive Biological Detection and Imaging", edited by Xiaohong Nancy Xu, Wiley-VCH Publishers, 2007

Presentations:
Sathe T.R., Saheb A., Nie S.M., Integrating Magnetic and Optical Nanotechnology for Selective Capture and Multiplexed Analysis of Rare Tumor Cells, Invited Talk, 6th IEEE Sensors Conference, Atlanta, October 29th, 2007.

Sathe T.R. and Nie S.M., "Integrated Dual-Modality Nanostructures for Bioanalytical Applications", Invited Talk, PITTCON, Chicago, February 26, 2007

Sathe T.R. and Nie S.M., "Development of dual-function microbeads embedded with quantum dots and iron oxide nanocrystals for biomedical applications", Invited Talk, Photonics West, San Jose, January 20, 2007

Sathe T.R, Xing Y., and Nie S.M., "Selective Capture and Profiling of Rare Circulating Tumor Cells Using Multicolor Quantum Dot Probes", Oral Presentation, BMES, Chicago, October 13, 2006

Agrawal A., Sathe T.R., and Nie S.M., "Nanotechnology for Immunochemistry and Detection of Infectious Agents", Oral Presentation, 232nd ACS National Meeting, San Francisco, September 12, 2006

• Sam A. Wilson Memorial Scholarship, Univ. of Oklahoma (2000-2001)
• Third Prize, Senior Design Competition, Dept. of Chemical Engineering, Univ. of Oklahoma
• Awarded Best Poster Prize, Emory-GT Center for Cancer Nanotechnology Excellence Symposium, 2007