Laboratories for Biomolecular Engineering & Nanotechnology

Group Members

Debatosh Majumdar

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E-mail:		dmajumd@emory.edu

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Education l Research Summary l Publications l Fellowships l Honors & Awards

Education

Complex Carbohydrate Research Center University of Georgia Department of Chemistry Ph.D. in Organic Chemistry	08/99-07/04

Indian Institute of Technology Kanpur Kanpur, U.P. Department of Chemistry Masters (M.S) in Chemistry	08/93-06/96

University of Calcutta Bachelors (B.Sc. Honors) in Chemistry	08/90-07/93

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Research Summary

Experienced organic and medicinal chemist with experience in the synthesis of biologically important molecules, good background in nanotechnology, biochemistry, protease inhibitors, carbohydrates and glyco-conjugates, natural product analogs, peptides and derivatives, solid-phase synthesis, organophosphorous chemistry, enzymatic reactions, drug discovery, drug delivery, and nanotechnology in cancer therapy with research interest in medicinally important chemistry for treatment of cancer, and use of nanotechnology in cancer therapy, both diagnosis of cancer and treatment of cancer.

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Publications and Presentation

Publications:

Design and Synthesis of Epoxides of the Olefin Isostere of the g-Glutamyl Dipeptide as Inhibitors for the Cysteine Protease g-Glutamyl Hydrolase. Majumdar, D.; Alexander, M. D.; Coward, J. K. 2007 Journal of Organic Chemistry (manuscript is ready, soon to be in press).

Synthesis of Proteophosphoglycans of Leishmania major and Leishmania mexicana A New Class of Glycosylated Phosphopeptides. Majumdar, D.; Galal El Sayed.; Buskas, T.; Boons, G.J. Journal of Organic Chemistry 2005, 70, 1691-1697.

The Use of Solvent Acetonitrile in Stereoselective Glycosylations. Majumdar, D.; Boons, G.J. Encyclopedia of Reagents for Organic Synthesis 2004, 6.

Synthesis of Oligosaccharides on Soluble High-Molecular-Weight Branched Polymers In Combination with Purification by Nanofiltration. Majumdar, D.; Zhu, T.; Boons, G.J. Organic Letters 2003, 5, 3591-3594.

Presentations:

National Cancer Institute Nanotechnology Alliance Investigators Meeting 2007, Chapel Hill, NC.
National Meeting of the American Chemical Society 2006, San Francisco, CA.
Midwest Enzyme Chemistry Conference 2005, Chicago, IL.
Carbohydrates Gordon Research Conference 2003, Tilton, NH.
Southeast Regional Meeting of the American Chemical Society 2003, Atlanta, GA.
Proctor & Gamble Poster Competition 2003, University of Georgia, Athens, GA.
Proctor & Gamble Poster Competition 2002, University of Georgia, Athens, GA.
Department of Chemistry Seminar 2001, University of Georgia, Athens, GA

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Fellowships

Emory-GT Center for Cancer Nanotechnology Excellence
Atlanta, GA
The Wallace H. Coulter Department of Biomedical Engineering
Distinguished Research Fellow
December 2006-August 2008
Project: Use of nanotechnology in cancer therapy. Design and synthesis of nanoscale system which can be used in cancer therapy and in imaging of cancer.

University of Michigan
Ann Arbor, MI
Departments of Medicinal Chemistry and Chemistry
Research Fellow
September 2004-November 2006
Project: The design and synthesis of the epoxide derivatives of olefin isostere of g-glutamyl dipeptide from ethyl-2-oxocyclopentane carboxylate and their biological evaluation as inhibitors for the cysteine protease, g-glutamyl hydrolase (GH). Key reactions: asymmetric epoxidation, Julia-Kocienski olefination, Grubb’s olefin metathesis, Chugaev reaction, Mitsunobu reaction, oxidations, enzymatic reactions catalyzed by Saccharomyces cerevisiae and Lipase from Pseudomonas fluorescens Wittig olefination.

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Honors and Awards

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